Antimicrobial stewardship programmes focused on de-escalation: a narrative review of efficacy and risks

Background and Objective: Multi-drug resistance is an increasing problem associated with increased morbidity mortality. High levels of antimicrobial consumption broad-spectrum use are (AMR). Studies have shown substantial across intensive care units (ICUs) worldwide. International guidelines advise antibiotic de-escalation (ADE) as part stewardship programme (ASP). ADE a strategy to decrease the spectrum empirical therapy, aim reduce ecological impact on patient’s microbiome emergence AMR. Our was provide insight into latest developments in setting.